The antinematodal activity of some wild plant extracts located in North and South Sinai, Egypt was examined against root-knot nematode (RKN). The selected seven plants viz., Artemisia judaica, A. monosperma, Bassia muricata, Cornulaca monacantha, Salsola kali and Zygophyllum album with different dilutions (25%, 50%, 75% &100%). The potent nematicidal efficacy observed in the extract of A. judaica followed by A. monosperma. In vivo trial post inoculation treatments were effective than pre one, the maximum reduction in nematode population was recorded by A. judaica (87.0%) followed by A. monosperma (83.0%) then Z. album1 (79.0%), while the lowest suppressor was C. monacantha (60.4%) at stock concentration. The addition of extracts as soil drench was better than spraying them. The stock solution showed the highest reduction in nematode reproduction but the differences between 100% and 75% concentrations were non-significant. Our finding offers a non-poisonous tool that can insert in combating nematode programs especially for small-holder growers colonized Sinai Peninsula.