The study was carried out to screen the vermicidal activity of various homeopathic medicines at 100, 75 and 50% v/v concentrations of different potencies including mother tincture (Q), 200C and 30C against root-knot nematode Meloidogyne javanica using hatching and mortality test at different time intervals. Notable results were noticed by Kent-20 and Santonine-43 at all tested concentrations by reducing the hatching and complete mortality of M. javanica after 96 hours, while Cina (Q) showed greater reduction in hatching and mortality at 100% concentration followed by minimum hatching of eggs when used at 75 and 50% concentrations but in case of 200 and 30 (C) potency, only 100% concentration showed maximum effect after 72 and 96 hours followed by 75% concentration which had slight effect, whereas 50% concentration found to fail in killing the second stage of juveniles. Other homeopathic drugs used in the experiment showed no significant nematicidal effect against M. incognita. Kent-20 and Santonine-43 at three different concentrations of 50, 100 and 75% was highly effective when used as seed treatment of okra, sunflower, mung bean and mash beans followed by drenching the soil with these concentrations of both homeopathic drugs separately, also resulted in increasing the weight and height of tested crops and reducing the nematode infection on roots plant.